Hypoxia-Inducible Factor–Prolyl Hydroxylase Inhibitor Improves Leukocyte Energy Metabolism in Hereditary Hemorrhagic Telangiectasia

Hypoxia-Inducible Factor–Prolyl Hydroxylase Inhibitor Improves Leukocyte Energy Metabolism in Hereditary Hemorrhagic Telangiectasia

The interplay between hypoxia-inducible factors (HIFs) and transforming growth factor beta (TGF-β) is critical for both inflammation and angiogenesis. In hereditary hemorrhagic telangiectasia (HHT), we have previously observed that impairment of the TGF-β pathway is associated with downregulation of...

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Bibliographic Details
Main Authors: Yves Schild, Jonah Bosserhoff, Freya Droege, Elisabeth Littwitz-Salomon, Joachim Fandrey, Anna Wrobeln
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Life
Subjects:
hypoxia-inducible factor
HIF
leukocytes
PBMC
hereditary hemorrhagic telangiectasia
HHT
Online Access:https://www.mdpi.com/2075-1729/13/8/1708

Internet

https://www.mdpi.com/2075-1729/13/8/1708

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