Manganese is a physiologically relevant TORC1 activator in yeast and mammals

Manganese is a physiologically relevant TORC1 activator in yeast and mammals

The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human diseases. Whether intracellular Mn levels may be sensed and modulate intracellular signaling events has so far remained largely unexplored. The highly conserved target of rapam...

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Bibliographic Details
Main Authors: Raffaele Nicastro, Hélène Gaillard, Laura Zarzuela, Marie-Pierre Péli-Gulli, Elisabet Fernández-García, Mercedes Tomé, Néstor García-Rodríguez, Raúl V Durán, Claudio De Virgilio, Ralf Erik Wellinger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
manganese
TORC1
NRAMP transporter
autophagy
mitophagy
Online Access:https://elifesciences.org/articles/80497

Internet

https://elifesciences.org/articles/80497

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