An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses

An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses

Summary: CD137 is a costimulatory receptor expressed on natural killer cells, T cells, and subsets of dendritic cells. An agonistic monoclonal antibody (mAb) against CD137 has been used to reduce tumor burden or reverse autoimmunity in animal models and clinical trials. Here, we show that mice treat...

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Bibliographic Details
Main Authors: Jun P. Hong, Glennys V. Reynoso, Prabhakar S. Andhey, Amanda Swain, Jackson S. Turner, Adrianus C.M. Boon, Florian Krammer, Ali H. Ellebedy, Fabio Zanini, Maxim Artyomov, Heather D. Hickman, Michael S. Diamond
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports Medicine
Subjects:
antibody
germinal center
CD137
memory B cell
T cell-dependent
single cell RNA sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379120300471

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http://www.sciencedirect.com/science/article/pii/S2666379120300471

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