Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction

Role and mechanism of REG2 depletion in insulin secretion augmented by glutathione peroxidase-1 overproduction

We previously reported a depletion of murine regenerating islet-derived protein 2 (REG2) in pancreatic islets of glutathione peroxidase-1 (Gpx1) overexpressing (OE) mice. The present study was to explore if and how the REG2 depletion contributed to an augmented glucose stimulated insulin secretion (...

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Bibliographic Details
Main Authors: Xi Yan, Zeping Zhao, Jeremy Weaver, Tao Sun, Jun-Won Yun, Carol A. Roneker, Fenghua Hu, Nicolai M. Doliba, Charles Chipley W. McCormick, Marko Z. Vatamaniuk, Xin Gen Lei
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Redox Biology
Subjects:
Regenerating islet-derived protein
Glutathione peroxidase
L-type voltage-dependent calcium channel
Glucose-stimulated insulin secretion
Protein-protein interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722002294

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http://www.sciencedirect.com/science/article/pii/S2213231722002294

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