A conserved MCM single-stranded DNA binding element is essential for replication initiation

A conserved MCM single-stranded DNA binding element is essential for replication initiation

The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA. Helicase activation converts this species to two active single hexamers that encircle single-stranded DNA (ssDNA). The molecular d...

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Bibliographic Details
Main Authors: Clifford A Froelich, Sukhyun Kang, Leslie B Epling, Stephen P Bell, Eric J Enemark
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
DNA replication
helicase
crystallography
genetic
archaea
Online Access:https://elifesciences.org/articles/01993

Internet

https://elifesciences.org/articles/01993

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