Identifying hub genes of calcific aortic valve disease and revealing the immune infiltration landscape based on multiple WGCNA and single-cell sequence analysis

Identifying hub genes of calcific aortic valve disease and revealing the immune infiltration landscape based on multiple WGCNA and single-cell sequence analysis

BackgroundCalcific aortic valve disease (CAVD) is a progressive fibrocalcific disease that can be treated only through valve replacement. This study aimed to determine the role of hub genes and immune cell infiltration in CAVD progression.MethodsIn this study, bioinformatics analysis was used to ide...

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Bibliographic Details
Main Authors: Kan Wang, Qiang Zheng, Xing Liu, BingChuan Geng, NianGuo Dong, JiaWei Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
calcific aortic valve diseases (CAVD)
DEGs
weighted gene co-expression network analysis (WGCNA)
single cell sequence (scRNA-seq)
immune infiltration
bioinformatics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1035285/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1035285/full

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