The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of Granzymes

The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of Granzymes

The transcription factor Tcf1 is essential for the development of natural killer (NK) cells. However, its precise role has not been clarified. Our combined analysis of Tcf1-deficient and transgenic mice indicated that Tcf1 guides NK cells through three stages of development. Tcf1 expression directed...

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Bibliographic Details
Main Authors: Beena Jeevan-Raj, Jasmine Gehrig, Mélanie Charmoy, Vijaykumar Chennupati, Camille Grandclément, Paolo Angelino, Mauro Delorenzi, Werner Held
Format: Article
Language:English
Published: Elsevier 2017-07-01
Series:Cell Reports
Subjects:
NK cells
T cell factor 1
Tcf1
granzyme B
self-destruction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717309026

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http://www.sciencedirect.com/science/article/pii/S2211124717309026

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