LINE-1 ORF2p expression is nearly imperceptible in human cancers

LINE-1 ORF2p expression is nearly imperceptible in human cancers

Abstract Background Long interspersed element-1 (LINE-1, L1) is the major driver of mobile DNA activity in modern humans. When expressed, LINE-1 loci produce bicistronic transcripts encoding two proteins essential for retrotransposition, ORF1p and ORF2p. Many types of human cancers are characterized...

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Main Authors: Daniel Ardeljan, Xuya Wang, Mehrnoosh Oghbaie, Martin S. Taylor, David Husband, Vikram Deshpande, Jared P. Steranka, Mikhail Gorbounov, Wan Rou Yang, Brandon Sie, H. Benjamin Larman, Hua Jiang, Kelly R. Molloy, Ilya Altukhov, Zhi Li, Wilson McKerrow, David Fenyö, Kathleen H. Burns, John LaCava
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Mobile DNA
Online Access:https://doi.org/10.1186/s13100-019-0191-2

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https://doi.org/10.1186/s13100-019-0191-2

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