Intrahepatic macrophage reprogramming associated with lipid metabolism in hepatitis B virus-related acute-on-chronic liver failure

Intrahepatic macrophage reprogramming associated with lipid metabolism in hepatitis B virus-related acute-on-chronic liver failure

Abstract Background Acute-on-chronic liver failure (ACLF) is a severe syndrome with high short-term mortality, but the pathophysiology still remains largely unknown. Immune dysregulation and metabolic disorders contribute to the progression of ACLF, but the crosstalk between immunity and metabolism...

Full description

Bibliographic Details
Main Authors: Bo Peng, Hao Li, Kai Liu, Pengpeng Zhang, Quan Zhuang, Junhui Li, Min Yang, Ke Cheng, Yingzi Ming
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Translational Medicine
Subjects:
Acute-on-chronic liver failure
Hepatitis B virus
scRNA-seq
TREM2
Lipid metabolomics
Free fatty acids
Online Access:https://doi.org/10.1186/s12967-023-04294-1

Internet

https://doi.org/10.1186/s12967-023-04294-1

Similar Items