Intrahepatic macrophage reprogramming associated with lipid metabolism in hepatitis B virus-related acute-on-chronic liver failure

Intrahepatic macrophage reprogramming associated with lipid metabolism in hepatitis B virus-related acute-on-chronic liver failure

Abstract Background Acute-on-chronic liver failure (ACLF) is a severe syndrome with high short-term mortality, but the pathophysiology still remains largely unknown. Immune dysregulation and metabolic disorders contribute to the progression of ACLF, but the crosstalk between immunity and metabolism...

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Bibliographic Details
Main Authors:	Bo Peng, Hao Li, Kai Liu, Pengpeng Zhang, Quan Zhuang, Junhui Li, Min Yang, Ke Cheng, Yingzi Ming
Format:	Article
Language:	English
Published:	BMC 2023-06-01
Series:	Journal of Translational Medicine
Subjects:	Acute-on-chronic liver failure Hepatitis B virus scRNA-seq TREM2 Lipid metabolomics Free fatty acids
Online Access:	https://doi.org/10.1186/s12967-023-04294-1

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