Deep Mutational Scanning to Map How Zika Envelope Protein Mutations Affect Viral Growth and Antibody Escape

The Zika virus has recently been shown to be associated with severe birth defects. The virus’ envelope (E) protein mediates its ability to infect cells and is also the primary target of the antibodies that are elicited by natural infection and the vaccines that are being developed against the virus....

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Bibliographic Details
Main Authors: Marion Sourisseau, Daniel J. P. Lawrence, Megan C. Schwarz, Carina H. Storrs, Ethan C. Veit, Jesse D. Bloom, Matthew J. Evans
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Proceedings
Subjects:
Online Access:https://www.mdpi.com/2504-3900/50/1/93