Discovery of small molecule inhibitors of Mycobacterium tuberculosis ClpC1: SAR studies and antimycobacterial evaluation

Discovery of small molecule inhibitors of Mycobacterium tuberculosis ClpC1: SAR studies and antimycobacterial evaluation

The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) in humans, is a primary reason for treatment failure. Currently, only limited options are available for the management of multi-drug resistant TB, warranting the design of novel anti...

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Bibliographic Details
Main Authors: Amritansh Bhanot, Ajitesh Lunge, Naresh Kumar, Saqib Kidwai, Ramandeep Singh, Sandeep Sundriyal, Nisheeth Agarwal
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Results in Chemistry
Subjects:
Mycobacterium
Protease
ClpC1
Synthesis
Molecular docking
Quinoline
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715623001431

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http://www.sciencedirect.com/science/article/pii/S2211715623001431

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