Rapamycin inhibits hepatitis B virus covalently closed circular DNA transcription by enhancing the ubiquitination of HBx

Rapamycin inhibits hepatitis B virus covalently closed circular DNA transcription by enhancing the ubiquitination of HBx

Hepatitis B virus (HBV) infection is still a serious public health problem worldwide. Antiviral therapies such as interferon and nucleos(t)ide analogs efficiently control HBV replication, but they cannot eradicate chronic hepatitis B (CHB) because of their incapacity to eliminate endocellular covale...

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Bibliographic Details
Main Authors: Yuan Zhang, Liang Li, Sheng-Tao Cheng, Yi-Ping Qin, Xin He, Fan Li, Dai-Qing Wu, Fang Ren, Hai-Bo Yu, Jing Liu, Juan Chen, Ji-Hua Ren, Zhen-Zhen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Microbiology
Subjects:
rapamycin
hepatitis B virus
HBx
covalently closed circular DNA
transcription
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.850087/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.850087/full

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