Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity

Reciprocal Regulation of KCC2 Trafficking and Synaptic Activity

The main inhibitory neurotransmitter receptors in the adult central nervous system (CNS) are type A γ-aminobutyric acid receptors (GABAARs) and glycine receptors (GlyRs). Synaptic responses mediated by GlyR and GABAAR display a hyperpolarizing shift during development. This shift relies mainly on th...

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Bibliographic Details
Main Authors: Etienne Côme, Martin Heubl, Eric J. Schwartz, Jean Christophe Poncer, Sabine Lévi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
GABAAR
chloride homeostasis
membrane turnover
lateral diffusion
clustering
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00048/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00048/full

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