ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer

ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer

Conventional mitogen-activated protein kinase (MAPK) family members regulate diverse cellular processes involved in tumor initiation and progression, yet the role of ERK5 in cancer biology is not fully understood. Triple-negative breast cancer (TNBC) presents a clinical challenge due to the aggressi...

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Bibliographic Details
Main Authors: Van T. Hoang, Margarite D. Matossian, Deniz A. Ucar, Steven Elliott, Jacqueline La, Maryl K. Wright, Hope E. Burks, Aaron Perles, Fokhrul Hossain, Connor T. King, Valentino E. Browning, Jacob Bursavich, Fang Fang, Luis Del Valle, Akshita B. Bhatt, Jane E. Cavanaugh, Patrick T. Flaherty, Muralidharan Anbalagan, Brian G. Rowan, Melyssa R. Bratton, Kenneth P. Nephew, Lucio Miele, Bridgette M. Collins-Burow, Elizabeth C. Martin, Matthew E. Burow
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Oncology
Subjects:
ERK5 kinase
triple negative breast cancer (TNBC)
clustered regularly interspaced short palindromic repeats (CRISPR) knockout
extracelluar matix
metastasis
epithelial–mesenchymal–transition
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01164/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.01164/full

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