Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease

Identification of Gut Microbial Lysine and Histidine Degradation and CYP-Dependent Metabolites as Biomarkers of Fatty Liver Disease

ABSTRACT Numerous studies have described specific metabolites as biomarkers of severe liver diseases, but very few have measured gut microbiota (GM)-produced metabolites in fatty liver disease. We aimed at finding GM signatures and metabolite markers in plasma and feces related to high liver fat con...

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Bibliographic Details
Main Authors: Anastasiia Driuchina, Jukka Hintikka, Marko Lehtonen, Pekka Keski-Rahkonen, Thomas O’Connell, Risto Juvonen, Juho Kuula, Antti Hakkarainen, Jari A. Laukkanen, Elina Mäkinen, Sanna Lensu, Kirsi H. Pietiläinen, Satu Pekkala
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mBio
Subjects:
gut microbiota
insulin resistance
liver fat
metabolomics
Online Access:https://journals.asm.org/doi/10.1128/mbio.02663-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02663-22

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