Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA. We identified fragile X mental retardation protein (FMRP) as...

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Bibliographic Details
Main Authors: Ruben Soto-Acosta, Xuping Xie, Chao Shan, Coleman K Baker, Pei-Yong Shi, Shannan L Rossi, Mariano A Garcia-Blanco, Shelton Bradrick
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
Zika virus
RNA-binding protein
translation
Online Access:https://elifesciences.org/articles/39023

Internet

https://elifesciences.org/articles/39023

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