KIR-HLA interactions extend human CD8+ T cell lifespan in vivo

KIR-HLA interactions extend human CD8+ T cell lifespan in vivo

BACKGROUND There is increasing evidence, in transgenic mice and in vitro, that inhibitory killer cell immunoglobulin-like receptors (iKIRs) can modulate T cell responses. Furthermore, we have previously shown that iKIRs are an important determinant of T cell–mediated control of chronic viral infecti...

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Bibliographic Details
Main Authors: Yan Zhang, Ada W.C. Yan, Lies Boelen, Linda Hadcocks, Arafa Salam, Daniel Padrosa Gispert, Loiza Spanos, Laura Mora Bitria, Neda Nemat-Gorgani, James A. Traherne, Chrissy Roberts, Danai Koftori, Graham P. Taylor, Daniel Forton, Paul J. Norman, Steven G.E. Marsh, Robert Busch, Derek C. Macallan, Becca Asquith
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-06-01
Series:The Journal of Clinical Investigation
Subjects:
Immunology
Online Access:https://doi.org/10.1172/JCI169496

Internet

https://doi.org/10.1172/JCI169496

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