Unveiling the Role of Protein Kinase C θ in Porcine Epidemic Diarrhea Virus Replication: Insights from Genome-Wide CRISPR/Cas9 Library Screening

Unveiling the Role of Protein Kinase C θ in Porcine Epidemic Diarrhea Virus Replication: Insights from Genome-Wide CRISPR/Cas9 Library Screening

Porcine epidemic diarrhea virus (PEDV), a member of the Alpha-coronavirus genus in the Coronaviridae family, induces acute diarrhea, vomiting, and dehydration in neonatal piglets. This study aimed to investigate the genetic dependencies of PEDV and identify potential therapeutic targets by using a s...

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Bibliographic Details
Main Authors: Jinglin Zhou, Zhihua Feng, Deyang Lv, Duokai Wang, Kai Sang, Zhihao Liu, Dong Guo, Yangkun Shen, Qi Chen
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
genome-scale CRISPR screen
PEDV (porcine epidemic diarrhea virus)
susceptibility
PKCθ (protein kinase C θ)
BOK (B-cell lymphoma 2 (BCL-2) ovarian killer)
mitochondrial apoptosis
Online Access:https://www.mdpi.com/1422-0067/25/6/3096

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https://www.mdpi.com/1422-0067/25/6/3096

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