In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model

In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic β-Cell Model

There is a need to develop identification tests for Metabolism Disrupting Chemicals (MDCs) with diabetogenic activity. Here we used the human EndoC-βH1 β-cell line, the rat β-cell line INS-1E and dispersed mouse islet cells to assess the effects of endocrine disruptors on cell viability and glucose-...

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Bibliographic Details
Main Authors: Reinaldo Sousa Dos Santos, Regla María Medina-Gali, Ignacio Babiloni-Chust, Laura Marroqui, Angel Nadal
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
apoptosis
diabetes
endocrine disruptors
insulin secretion
metabolism disrupting chemicals
pancreatic β-cells
Online Access:https://www.mdpi.com/1422-0067/23/9/5040

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https://www.mdpi.com/1422-0067/23/9/5040

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