Therapeutic CCR2 Blockade Prevents Inflammation and Alleviates Myxomatous Valve Disease in Marfan Syndrome

Therapeutic CCR2 Blockade Prevents Inflammation and Alleviates Myxomatous Valve Disease in Marfan Syndrome

Summary: Myxomatous valve disease (MVD) can lead to cardiac dysfunction and heart failure, yet medical therapies are lacking. C-C chemokine receptor type 2 (CCR2)+ immune cell infiltration promotes mitral valve inflammation in a Marfan syndrome (MFS) mouse model. The CCR2 genetic knockout reduces in...

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Bibliographic Details
Main Authors: Na Xu, PhD, Katherine E. Yutzey, PhD
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:JACC: Basic to Translational Science
Subjects:
C-C chemokine receptor type 2
extracellular matrix
inflammation
myxomatous valve disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X22002182

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http://www.sciencedirect.com/science/article/pii/S2452302X22002182

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