Extensive Bioinformatics Analyses Reveal a Phylogenetically Conserved Winged Helix (WH) Domain (Zτ) of Topoisomerase IIα, Elucidating Its Very High Affinity for Left-Handed Z-DNA and Suggesting Novel Putative Functions

Extensive Bioinformatics Analyses Reveal a Phylogenetically Conserved Winged Helix (WH) Domain (Zτ) of Topoisomerase IIα, Elucidating Its Very High Affinity for Left-Handed Z-DNA and Suggesting Novel Putative Functions

The dynamic processes operating on genomic DNA, such as gene expression and cellular division, lead inexorably to topological challenges in the form of entanglements, catenanes, knots, “bubbles”, R-loops, and other outcomes of supercoiling and helical disruption. The resolution of toxic topological...

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Bibliographic Details
Main Authors: Martin Bartas, Kristyna Slychko, Jiří Červeň, Petr Pečinka, Donna J. Arndt-Jovin, Thomas M. Jovin
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
Z-DNA
topoisomerase IIα
topoII
GTP
bioinformatics
Online Access:https://www.mdpi.com/1422-0067/24/13/10740

Internet

https://www.mdpi.com/1422-0067/24/13/10740

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