Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast ReprogrammingSummary

Extrinsic KRAS Signaling Shapes the Pancreatic Microenvironment Through Fibroblast ReprogrammingSummary

Background & Aims: Oncogenic Kirsten Rat Sarcoma virus (KRAS) is the hallmark mutation of human pancreatic cancer and a driver of tumorigenesis in genetically engineered mouse models of the disease. Although the tumor cell–intrinsic effects of oncogenic Kras expression have been widely studi...

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Bibliographic Details
Main Authors: Ashley Velez-Delgado, Katelyn L. Donahue, Kristee L. Brown, Wenting Du, Valerie Irizarry-Negron, Rosa E. Menjivar, Emily L. Lasse Opsahl, Nina G. Steele, Stephanie The, Jenny Lazarus, Veerin R. Sirihorachai, Wei Yan, Samantha B. Kemp, Samuel A. Kerk, Murali Bollampally, Sion Yang, Michael K. Scales, Faith R. Avritt, Fatima Lima, Costas A. Lyssiotis, Arvind Rao, Howard C. Crawford, Filip Bednar, Timothy L. Frankel, Benjamin L. Allen, Yaqing Zhang, Marina Pasca di Magliano
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Pancreatic Cancer
Transformation
Fibroblasts
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X22000431

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http://www.sciencedirect.com/science/article/pii/S2352345X22000431

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