Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice.

Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice.

OBJECTIVE:Most anti-angiogenic preeclampsia models in rodents utilized the overexpression of a truncated soluble fms-like tyrosine kinase-1 (sFlt-1) not expressed in any species. Other limitations of mouse preeclampsia models included stressful blood pressure measurements and the lack of postpartum...

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Bibliographic Details
Main Authors: Gabor Szalai, Roberto Romero, Tinnakorn Chaiworapongsa, Yi Xu, Bing Wang, Hyunyoung Ahn, Zhonghui Xu, Po Jen Chiang, Birgitta Sundell, Rona Wang, Yang Jiang, Olesya Plazyo, Mary Olive, Adi L Tarca, Zhong Dong, Faisal Qureshi, Zoltan Papp, Sonia S Hassan, Edgar Hernandez-Andrade, Nandor Gabor Than
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4393117?pdf=render

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http://europepmc.org/articles/PMC4393117?pdf=render

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