The mitochondria-targeted sulfide delivery molecule attenuates drugs-induced gastropathy. Involvement of heme oxygenase pathway.

The mitochondria-targeted sulfide delivery molecule attenuates drugs-induced gastropathy. Involvement of heme oxygenase pathway.

Hydrogen sulfide (H2S) signaling and H2S-prodrugs maintain redox balance in gastrointestinal (GI) tract. Predominant effect of any H2S-donor is mitochondrial. Non-targeted H2S-moieties were shown to decrease the non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastrotoxicity but in high doses....

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Bibliographic Details
Main Authors: Katarzyna Magierowska, Dagmara Wójcik-Grzybek, Edyta Korbut, Dominik Bakalarz, Grzegorz Ginter, Aleksandra Danielak, Sławomir Kwiecień, Anna Chmura, Roberta Torregrossa, Matthew Whiteman, Marcin Magierowski
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Redox Biology
Subjects:
Gastric mucosa
Hydrogen sulfide
Heme oxygenase
Mitochondria
Non-steroidal anti-inflammatory drugs
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002483

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http://www.sciencedirect.com/science/article/pii/S2213231723002483

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