Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin <i>versus</i> <i>trans</i>-6-Styrylcoumarin

Coumarin-Resveratrol-Inspired Hybrids as Monoamine Oxidase B Inhibitors: 3-Phenylcoumarin <i>versus</i> <i>trans</i>-6-Styrylcoumarin

Monoamine oxidases (MAOs) are attractive targets in drug design. The inhibition of one of the isoforms (A or B) is responsible for modulating the levels of different neurotransmitters in the central nervous system, as well as the production of reactive oxygen species. Molecules that act selectively...

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Bibliographic Details
Main Authors: Marco Mellado, César González, Jaime Mella, Luis F. Aguilar, Ismail Celik, Fernanda Borges, Eugenio Uriarte, Giovanna Delogu, Dolores Viña, Maria J. Matos
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
3-phenylcoumarin
<i>trans</i>-6-styrylcoumarin
<i>trans</i>-resveratrol
monoamine oxidase B inhibitors
3D-QSAR models
molecular docking
Online Access:https://www.mdpi.com/1420-3049/27/3/928

Internet

https://www.mdpi.com/1420-3049/27/3/928

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