A CCHFV DNA vaccine protects against heterologous challenge and establishes GP38 as immunorelevant in mice

A CCHFV DNA vaccine protects against heterologous challenge and establishes GP38 as immunorelevant in mice

Abstract Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that causes severe hemorrhagic fever disease in humans. Currently, no licensed CCHF vaccines exist, and the protective epitopes remain unclear. Previously, we tested a DNA vaccine expressing the M-segment glycoprotein precu...

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Bibliographic Details
Main Authors: John J. Suschak, Joseph W. Golden, Collin J. Fitzpatrick, Charles J. Shoemaker, Catherine V. Badger, Connie S. Schmaljohn, Aura R. Garrison
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-021-00293-9

Internet

https://doi.org/10.1038/s41541-021-00293-9

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