Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor‐associated macrophages

Hollow copper sulfide nanoparticles carrying ISRIB for the sensitized photothermal therapy of breast cancer and brain metastases through inhibiting stress granule formation and reprogramming tumor‐associated macrophages

As known, the benefits of photothermal therapy (PTT) are greatly limited by the heat tolerance of cancer cells resulting from overexpressed heat shock proteins (HSPs). Then HSPs further trigger the formation of stress granules (SGs) that regulate protein expression and cell viability under various s...

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Bibliographic Details
Main Authors: Fan Tong, Haili Hu, Yanyan Xu, Yang Zhou, Rou Xie, Ting Lei, Yufan Du, Wenqin Yang, Siqin He, Yuan Huang, Tao Gong, Huile Gao
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Hollow copper sulfide nanoparticles
Sensitized PTT
SG inhibition
TAMs repolarization
pH-driven targeting
Photothermal responsiveness
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522004555

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http://www.sciencedirect.com/science/article/pii/S2211383522004555

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