Affinity chromatography reveals direct binding of the GATA4–NKX2-5 interaction inhibitor (3i-1000) with GATA4

Abstract Heart failure is a serious medical condition with a poor prognosis. Current treatments can only help manage the symptoms and slow the progression of heart failure. However, there is currently no cure to prevent and reverse cardiac remodeling. Transcription factors are in a central role in v...

Full description

Bibliographic Details
Main Authors: Mikael Jumppanen, Sini M. Kinnunen, Matej Zore, Mika J. Välimäki, Virpi Talman, Gustav Boije af Gennäs, Heikki J. Ruskoaho, Jari Yli-Kauhaluoma
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-59418-4