Computational-Based Discovery of the Anti-Cancer Activities of Pyrrole-Based Compounds Targeting the Colchicine-Binding Site of Tubulin

Computational-Based Discovery of the Anti-Cancer Activities of Pyrrole-Based Compounds Targeting the Colchicine-Binding Site of Tubulin

Despite the tubulin-binding agents (TBAs) that are widely used in the clinic for cancer therapy, tumor resistance to TBAs (both inherited and acquired) significantly impairs their effectiveness, thereby decreasing overall survival (OS) and progression-free survival (PFS) rates, especially for the pa...

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Bibliographic Details
Main Authors: Sergei Boichuk, Kirill Syuzov, Firuza Bikinieva, Aigul Galembikova, Svetlana Zykova, Ksenia Gankova, Sergei Igidov, Nazim Igidov
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
microtubules
ethyl-2-amino pyrrole-based carboxylates (EAPCs)
tubulin depolymerization
cell cycle
mitotic arrest
apoptosis
Online Access:https://www.mdpi.com/1420-3049/27/9/2873

Internet

https://www.mdpi.com/1420-3049/27/9/2873

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