A Novel Serine Protease Inhibitor PE-BBI Ameliorates Cockroach Extract-Mediated Airway Epithelial Barrier Dysfunction

Epithelial barrier dysfunction, characteristic of allergic airway disease may be, at least in part, due to the action of allergen-associated protease activities. Cockroach allergy is a major global health issue, with cockroaches containing considerable serine trypsin-like protease (TLP) activity. Th...

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Bibliographic Details
Main Authors: James A. Reihill, Xuan Ouyang, Zhixuan Yang, Lisa E. J. Douglas, Mei Zhou, Tianbao Chen, S. Lorraine Martin
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/10/4/515