A Novel Serine Protease Inhibitor PE-BBI Ameliorates Cockroach Extract-Mediated Airway Epithelial Barrier Dysfunction
Epithelial barrier dysfunction, characteristic of allergic airway disease may be, at least in part, due to the action of allergen-associated protease activities. Cockroach allergy is a major global health issue, with cockroaches containing considerable serine trypsin-like protease (TLP) activity. Th...
Main Authors: | James A. Reihill, Xuan Ouyang, Zhixuan Yang, Lisa E. J. Douglas, Mei Zhou, Tianbao Chen, S. Lorraine Martin |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-03-01
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Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/10/4/515 |
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