The Tumor Microenvironment and Strategies to Improve Drug Distribution

The microenvironment within tumors is composed of a heterogeneous mixture of cells with varying levels of nutrients and oxygen. Differences in oxygen content result in survival or compensatory mechanisms within tumors that may favor a more malignant or lethal phenotype. Cells that are rapidly prolif...

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Bibliographic Details
Main Authors: Jasdeep K Saggar, Man eYu, Qian eTan, Ian F Tannock
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-06-01
Series:Frontiers in Oncology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00154/full