The Tumor Microenvironment and Strategies to Improve Drug Distribution
The microenvironment within tumors is composed of a heterogeneous mixture of cells with varying levels of nutrients and oxygen. Differences in oxygen content result in survival or compensatory mechanisms within tumors that may favor a more malignant or lethal phenotype. Cells that are rapidly prolif...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00154/full |
| _version_ | 1828782458752991232 |
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| author | Jasdeep K Saggar Man eYu Qian eTan Ian F Tannock |
| author_facet | Jasdeep K Saggar Man eYu Qian eTan Ian F Tannock |
| author_sort | Jasdeep K Saggar |
| collection | DOAJ |
| description | The microenvironment within tumors is composed of a heterogeneous mixture of cells with varying levels of nutrients and oxygen. Differences in oxygen content result in survival or compensatory mechanisms within tumors that may favor a more malignant or lethal phenotype. Cells that are rapidly proliferating are richly nourished and preferentially located close to blood vessels. Chemotherapy can target and kill cells that are adjacent to the vasculature, while cells that reside farther away are often not exposed to adequate amounts of drug and may survive and repopulate following treatment. The characteristics of the tumor microenvironment can be manipulated in order to design more effective therapies. In this review, we describe important features of the tumor microenvironment and discuss strategies whereby drug distribution and activity may be improved. |
| first_indexed | 2024-12-11T17:48:58Z |
| format | Article |
| id | doaj.art-2034442fa9b04b4397dc380e3530eaa7 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T17:48:58Z |
| publishDate | 2013-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2034442fa9b04b4397dc380e3530eaa72022-12-22T00:56:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2013-06-01310.3389/fonc.2013.0015455160The Tumor Microenvironment and Strategies to Improve Drug DistributionJasdeep K Saggar0Man eYu1Qian eTan2Ian F Tannock3University of Toronto, Princess Margaret Cancer Centre/Ontario Cancer InstituteUniversity of Toronto, Princess Margaret Cancer Centre/Ontario Cancer InstituteUniversity of Toronto, Princess Margaret Cancer Centre/Ontario Cancer InstitutePrincess Margaret Cancer Centre/Ontario Cancer InstituteThe microenvironment within tumors is composed of a heterogeneous mixture of cells with varying levels of nutrients and oxygen. Differences in oxygen content result in survival or compensatory mechanisms within tumors that may favor a more malignant or lethal phenotype. Cells that are rapidly proliferating are richly nourished and preferentially located close to blood vessels. Chemotherapy can target and kill cells that are adjacent to the vasculature, while cells that reside farther away are often not exposed to adequate amounts of drug and may survive and repopulate following treatment. The characteristics of the tumor microenvironment can be manipulated in order to design more effective therapies. In this review, we describe important features of the tumor microenvironment and discuss strategies whereby drug distribution and activity may be improved.http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00154/fullTumor Microenvironmenthypoxia inducible factor (HIF)interstitial fluid pressureSolid tumordrug distributionpharmacodynamic markers |
| spellingShingle | Jasdeep K Saggar Man eYu Qian eTan Ian F Tannock The Tumor Microenvironment and Strategies to Improve Drug Distribution Frontiers in Oncology Tumor Microenvironment hypoxia inducible factor (HIF) interstitial fluid pressure Solid tumor drug distribution pharmacodynamic markers |
| title | The Tumor Microenvironment and Strategies to Improve Drug Distribution |
| title_full | The Tumor Microenvironment and Strategies to Improve Drug Distribution |
| title_fullStr | The Tumor Microenvironment and Strategies to Improve Drug Distribution |
| title_full_unstemmed | The Tumor Microenvironment and Strategies to Improve Drug Distribution |
| title_short | The Tumor Microenvironment and Strategies to Improve Drug Distribution |
| title_sort | tumor microenvironment and strategies to improve drug distribution |
| topic | Tumor Microenvironment hypoxia inducible factor (HIF) interstitial fluid pressure Solid tumor drug distribution pharmacodynamic markers |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00154/full |
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