3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines inhibit tubulin polymerisation and act as anticancer agents

A series of cis-restricted 3-aryl-4-(3,4,5-trimethoxyphenyl)pyridines as novel tubulin polymerisation inhibitors was designed based on molecular docking. Compound 9p, exhibited potent antiproliferative activity against HeLa, MCF-7, and A549 cell lines. Mechanism studies indicated that 9p potently in...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Chao Wang, Yujing Zhang, Shanbo Yang, Lingyu Shi, Yutao Xiu, Yudong Wu, Hongfei Jiang
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Taylor & Francis Group 2024-12-01
Cyfres:Journal of Enzyme Inhibition and Medicinal Chemistry
Pynciau:
Mynediad Ar-lein:https://www.tandfonline.com/doi/10.1080/14756366.2023.2286939