Protocol for Facile Synthesis of Fmoc-N-Me-AA-OH Using 2-CTC Resin as Temporary and Reusable Protecting Group

Protocol for Facile Synthesis of Fmoc-N-Me-AA-OH Using 2-CTC Resin as Temporary and Reusable Protecting Group

One approach to enhance the bioavailability and half-life of peptides in vivo is through N-methylation of one or more of the amino acids within the peptide sequence. However, commercially available Fmoc-N-Me-AA-OHs are limited and often expensive. In this study, a solid-phase synthesis method for Fm...

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Bibliographic Details
Main Authors: Tanya Román, Gerardo Acosta, Constanza Cárdenas, Beatriz G. de la Torre, Fanny Guzmán, Fernando Albericio
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Methods and Protocols
Subjects:
2-CTC resin
N-methylation
alpha and beta amino acids
Online Access:https://www.mdpi.com/2409-9279/6/6/110

Internet

https://www.mdpi.com/2409-9279/6/6/110

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