Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA

Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA

Abstract Background N4-acetylcytidine (ac4C) as a significant RNA modification has been reported to maintain the stability of mRNA and to regulate the translation process. However, the roles of both ac4C and its ‘writer’ protein N-acetyltransferase 10 (NAT10) played in the disease especially colorec...

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Bibliographic Details
Main Authors: Chi Jin, Tuo Wang, Dongsheng Zhang, Peng Yang, Chuan Zhang, Wen Peng, Kangpeng Jin, Lu Wang, Jiahui Zhou, Chaofan Peng, Yuqian Tan, Jiangzhou Ji, Zhihao Chen, Qingyang Sun, Sheng Yang, Junwei Tang, Yifei Feng, Yueming Sun
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Colorectal cancer
RNA modification
Ac4C
NAT10
KIF23
Wnt/β-catenin pathway
Online Access:https://doi.org/10.1186/s13046-022-02551-7

Internet

https://doi.org/10.1186/s13046-022-02551-7

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