The combination of olaparib and camptothecin for effective radiosensitization

The combination of olaparib and camptothecin for effective radiosensitization

<p>Abstract</p> <p>Background</p> <p>Poly (ADP-ribose) polymerase-1 (PARP-1) is a key enzyme involved in the repair of radiation-induced single-strand DNA breaks. PARP inhibitors such as olaparib (KU-0059436, AZD-2281) enhance tumor sensitivity to radiation and to topoi...

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Bibliographic Details
Main Authors: Miura Katsutoshi, Sakata Koh-ichi, Someya Masanori, Matsumoto Yoshihisa, Matsumoto Hideki, Takahashi Akihisa, Hareyama Masato
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Radiation Oncology
Subjects:
PARP inihibitor
Olaparib
Camptothecin
Topoisomerase I inhibitor
Radiosensitization
Online Access:http://www.ro-journal.com/content/7/1/62

Internet

http://www.ro-journal.com/content/7/1/62

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