Antiviral Activity of a Cyclic Pro-Pro-<i>β<sup>3</sup></i>-HoPhe-Phe Tetrapeptide against HSV-1 and HAdV-5

The core of Cyclolinopeptide A (CLA, cyclo(LIILVPPFF)), responsible for its high immunosuppressive activity, contains a Pro-Pro-Phe-Phe sequence. A newly synthesized cyclic tetrapeptide, cyclo(Pro-Pro-<i>β<sup>3</sup></i>-HoPhe-Phe) (denoted as 4B8M) bearing the active sequen...

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Bibliographic Details
Main Authors: Ewa Zaczyńska, Krzysztof Kaczmarek, Janusz Zabrocki, Jolanta Artym, Michał Zimecki
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
Online Access:https://www.mdpi.com/1420-3049/27/11/3552