Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice

Using SRM-MS to quantify nuclear protein abundance differences between adipose tissue depots of insulin-resistant mice

Insulin resistance (IR) underlies metabolic disease. Visceral, but not subcutaneous, white adipose tissue (WAT) has been linked to the development of IR, potentially due to differences in regulatory protein abundance. Here we investigate how protein levels are changed in IR in different WAT depots b...

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Bibliographic Details
Main Authors: Asuka Ota, Kyle M. Kovary, Olivia H. Wu, Robert Ahrends, Wen-Jun Shen, Maria J. Costa, Brian J. Feldman, Fredric B. Kraemer, Mary N. Teruel
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Journal of Lipid Research
Subjects:
adipocytes
peroxisome proliferator-activated receptors
obesity
insulin resistance
quantitative proteomics
selected reaction monitoring mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520312463

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http://www.sciencedirect.com/science/article/pii/S0022227520312463

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