The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium

The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium

Epithelial morphogenesis and stability are essential for normal development and organ homeostasis. The mouse neural plate is a cuboidal epithelium that remodels into a columnar pseudostratified epithelium over the course of 24 hr. Here we show that the transition to a columnar epithelium fails in mu...

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Bibliographic Details
Main Authors: Joaquim Grego-Bessa, Joshua Bloomekatz, Pau Castel, Tatiana Omelchenko, José Baselga, Kathryn V Anderson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-01-01
Series:eLife
Subjects:
epithelial morphogenesis
neural tube defect
tumor suppressor
PI3 kinase
Online Access:https://elifesciences.org/articles/12034

Internet

https://elifesciences.org/articles/12034

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