Preparation and Microbiological Evaluation of Amphiphilic Kanamycin-Lipoamino Acid Ion-Pairs

Preparation and Microbiological Evaluation of Amphiphilic Kanamycin-Lipoamino Acid Ion-Pairs

Amphiphilic ion-pairs of kanamycin (KAN) were prepared by evaporation of a water-ethanol co-solution of KAN base and a lipoamino acid bearing a 12-carbon atoms alkyl side chain (LAA12), at different molar ratios. Infrared spectroscopy confirmed the structure of ion-pairs, while differential scannin...

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Bibliographic Details
Main Authors: Rosario Pignatello, Antonio Leonardi, Giulio Petronio Petronio, Barbara Ruozi, Giovanni Puglisi, Pio Maria Furneri
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Antibiotics
Subjects:
coevaporates
physical mixtures
ion-pairs
lipoamino acids
amphiphilicity
DSC
PXDR
antibacterial activity
MIC
E. coli
Online Access:http://www.mdpi.com/2079-6382/3/2/216

Internet

http://www.mdpi.com/2079-6382/3/2/216

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