Melittin Tryptophan Substitution with a Fluorescent Amino Acid Reveals the Structural Basis of Selective Antitumor Effect and Subcellular Localization in Tumor Cells

Melittin Tryptophan Substitution with a Fluorescent Amino Acid Reveals the Structural Basis of Selective Antitumor Effect and Subcellular Localization in Tumor Cells

Melittin is a membrane-active peptide with strong anticancer activity against various cancers. Despite decades of research, the role of the singular Trp in the anticancer activity and selectivity of melittin remains poorly understood. Here, we propose a theranostic solution based on the substitution...

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Bibliographic Details
Main Authors: Yonghui Lv, Xu Chen, Zhidong Chen, Zhanjun Shang, Yongxiao Li, Wanting Xu, Yuan Mo, Xinpei Wang, Daiyun Xu, Shengbin Li, Zhe Wang, Meiying Wu, Junqing Wang
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Toxins
Subjects:
melittin
Trp
Dap
AMCA
fluorescence
alpha helix
Online Access:https://www.mdpi.com/2072-6651/14/7/428

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https://www.mdpi.com/2072-6651/14/7/428

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