Non-Antimicrobial Adjuvant Therapy Using Ticagrelor Reduced Biofilm-Related Staphylococcus aureus Prosthetic Joint Infection

Non-Antimicrobial Adjuvant Therapy Using Ticagrelor Reduced Biofilm-Related Staphylococcus aureus Prosthetic Joint Infection

Background: Prosthetic joint infection (PJI), frequently caused by Staphylococcus aureus, leads to a significant arthroplasty failure rate. Biofilm is a crucial virulence factor of S. aureus that is intrinsic to the pathogenesis of PJI. Biofilm-related infections are recalcitrant to antibiotic treat...

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Bibliographic Details
Main Authors: Narayan Pant, Socorro Miranda-Hernandez, Catherine Rush, Jeffrey Warner, Damon P. Eisen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
biofilm-related prosthetic joint infection
adjuvant therapy
S. aureus
ticagrelor
animal model
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.927783/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.927783/full

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