Discovery of Potent Dual EGFR/HER2 Inhibitors Based on Thiophene Scaffold Targeting H1299 Lung Cancer Cell Line

Discovery of Potent Dual EGFR/HER2 Inhibitors Based on Thiophene Scaffold Targeting H1299 Lung Cancer Cell Line

Dual targeting of epidermal growth factor receptor (EGFR) and human EGFR-related receptor 2 (HER2) is a proven approach for the treatment of lung cancer. With the aim of discovering effective dual EGFR/HER2 inhibitors targeting non-small cell lung cancer cell line H1299, three series of thieno[2,3-d...

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Bibliographic Details
Main Authors: Ranza Elrayess, Yasmine M. Abdel Aziz, Mohamed Saleh Elgawish, Marwa Elewa, Asmaa S. A. Yassen, Sameh S. Elhady, Hosam A. Elshihawy, Mohamed M. Said
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Pharmaceuticals
Subjects:
thieno[2,3-d][1,2,3]triazine
acetamide
H1299
HER2
EGFR
Online Access:https://www.mdpi.com/1424-8247/14/1/9

Internet

https://www.mdpi.com/1424-8247/14/1/9

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