Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

Chromosome 11q loss and MYCN amplification demonstrate synthetic lethality with checkpoint kinase 1 inhibition in neuroblastoma

Neuroblastoma is the most common extracranial solid tumor found in children and despite intense multi-modal therapeutic approaches, low overall survival rates of high-risk patients persist. Tumors with heterozygous loss of chromosome 11q and MYCN amplification are two genetically distinct subsets of...

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Bibliographic Details
Main Authors: Kaylee M. Keller, Thomas F. Eleveld, Linda Schild, Kim van den Handel, Marlinde van den Boogaard, Vicky Amo-Addae, Selma Eising, Kimberley Ober, Bianca Koopmans, Leendert Looijenga, Godelieve A.M. Tytgat, Bauke Ylstra, Jan J. Molenaar, M. Emmy M. Dolman, Sander R. van Hooff
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Oncology
Subjects:
pediatric cancer
neuroblastoma
checkpoint kinase 1 (CHK1)
chromosome 11q deletion
MYCN amplification
prexasertib
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.929123/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.929123/full

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