Mucus Hypersecretion and Ciliary Impairment in Conducting Airway Contribute to Alveolar Mucus Plugging in Idiopathic Pulmonary Fibrosis

Mucus Hypersecretion and Ciliary Impairment in Conducting Airway Contribute to Alveolar Mucus Plugging in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease attributed to the complex interplay of genetic and environmental risks. The muco-ciliary clearance (MCC) system plays a critical role in maintaining the conduit for air to and from the alveoli, but it remains poorly understood whether the...

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Bibliographic Details
Main Authors: Yang Peng, Zhao-Ni Wang, Ai-Ru Xu, Zhang-Fu Fang, Shi-Ying Chen, Xiao-Tao Hou, Zi-Qing Zhou, Hui-Min Lin, Jia-Xing Xie, Xiao Xiao Tang, De-Yun Wang, Nan-Shan Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
idiopathic pulmonary fibrosis
muco-ciliary clearance
MUC5B
conducting airway mucosa
mucus plugs
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.810842/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.810842/full

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