GRP78 inhibitor HA15 increases the effect of Bortezomib on eradicating multiple myeloma cells through triggering endoplasmic reticulum stress

GRP78 inhibitor HA15 increases the effect of Bortezomib on eradicating multiple myeloma cells through triggering endoplasmic reticulum stress

Bortezomib (BTZ), a selective proteasome inhibitor, exhibits a significant efficacy in the therapy of multiple myeloma (MM) partly through triggering endoplasmic reticulum (ER) stress-dependent apoptosis. However, sensitivity to BTZ varies greatly among patients. ER stress functions as a double-edge...

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Bibliographic Details
Main Authors: Yirong Chen, Yuchen Tao, Kexin Hu, Jiahui Lu
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Heliyon
Subjects:
Multiple myeloma
Bortezomib
ER stress
HA15
GRP78
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023070147

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http://www.sciencedirect.com/science/article/pii/S2405844023070147

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