Precise intracellular uptake and endosomal release of diverse functional mRNA payloads via glutathione-responsive nanogels

Precise intracellular uptake and endosomal release of diverse functional mRNA payloads via glutathione-responsive nanogels

We present a novel, highly customizable glutathione-responsive nanogel (NG) platform for efficient mRNA delivery with precise mRNA payload release control. Optimization of various cationic monomers, including newly synthesized cationic polyarginine, polyhistidine, and acrylated guanidine monomers, a...

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Bibliographic Details
Main Authors: Rupali Dabas, Naveenan Navaratnam, Haruki Iino, Saidbakhrom Saidjalolov, Stefan Matile, David Carling, David S. Rueda, Nazila Kamaly
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Materials Today Bio
Subjects:
Nanogels
Glutathione-responsive nanogels
disulphide crosslinker
mRNA delivery
AMPK
GFP mRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424004861

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http://www.sciencedirect.com/science/article/pii/S2590006424004861

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