Dexmedetomidine Alleviates Microglia-Induced Spinal Inflammation and Hyperalgesia in Neonatal Rats by Systemic Lipopolysaccharide Exposure

Dexmedetomidine Alleviates Microglia-Induced Spinal Inflammation and Hyperalgesia in Neonatal Rats by Systemic Lipopolysaccharide Exposure

Noxious stimulus and painful experience in early life can induce cognitive deficits and abnormal pain sensitivity. As a major component of the outer membrane of gram-negative bacteria, lipopolysaccharide (LPS) injection mimics clinical symptoms of bacterial infections. Spinal microglial activation a...

Full description

Bibliographic Details
Main Authors: Wen Wen, Xingrui Gong, Hoiyin Cheung, Yanyan Yang, Meihua Cai, Jijian Zheng, Xiaoping Tong, Mazhong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
lipopolysaccharide-induced inflammation
spinal cord
hyperalgesia
microglia
dexmedetomidine
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.725267/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2021.725267/full

Similar Items